Welcome to this issue

welcome to the first issue

Welcome and Introduction to the Inaugural Issue

Welcome to the Capstone Issue of NewsSpots

S years ago, in September 2002, the National Heart, Lung, and Blood Institute (NHLBI) activated research contracts with ten centers across the United States (see map) to enhance and develop innovative proteomic technologies and apply them to important biological questions relevant to knowledge of heart, lung, blood, and sleep health and disease. NewsSpots is the newsletter of the NHLBI Proteomi...

Editor’s Introduction to This Issue

With the recent development of high-throughput DNA microarray and next-generation sequencing techniques for detecting various genomic variants, genome-wide association studies (GWASs) have become a popular strategy to discover genetic factors affecting common complex diseases. Many GWASs have successfully identified genetic risk factors associated with common diseases and have achieved substant...

Editor's Introduction to This Issue

Next generation sequencing (NGS) has been facilitating the discovery and functional validation of causal variants in diverse rare diseases. However, for most of the 7,000 rare diseases, pathogenic mechanisms are still unknown. In this issue, Dr. Murim Choi's group (Seoul National University, Korea) comprehensively reviewed ultra-rare diseases and genomics-driven precision medicine. They present...